UBORA: Euro-African Open Biomedical Engineering e-Platform for innovation through Education

EU Commission, Horizon 2020, INFRASUPP-01-2016: Policy and international cooperation measures for research infrastructures. Objectives: The project aims at creating an EU-Africa e-Infrastructure, UBORA, for open source co-design of new solutions to face the current and future healthcare challenges of both continents, by exploiting networking, knowledge on rapid prototyping of new ideas and sharing of safety criteria and performance data. The e-Infrastructure will foster advances in education and the development of innovative solutions in Biomedical Engineering (BME), both of which are flywheels for European and African economies. In collaboration with: University of Pisa, KTH, University of Tartu, Uganda Industrial Research Institute, Kenyatta University, Agile Works.

ubora

TOMAX: Tool-less manufacture of complex geometries

  • “TOMAX: Tool-less manufacture of complex geometries”, EU Commission, Horizon 2020, Factories of the Future – FoF-02-2014-2015: Manufacturing processes for complex structures and geometries with efficient use of material. Objectives: The focus of the project is to unite industrial know-how in the field of software development, photopolymers and ceramics, high performance light-sources, system integration, life cycle analysis, industrial exploitation and rewarding end-user cases. The consortium will provide 3D-printers with high throughput and outstanding materials and energy efficiency. Targeted end-use applications include ceramics for aerospace engineering, medical devices and energy efficient lighting applications. In collaboration with: TU Wien, Lithoz GmbH (see prototypes below), Syalons Ltd, Rauschert GmbH, OSRAM, Research to Market, Deskartes, Cycleco, Invision. tomax-h2020.eu

tomax1

Knowledge-based tissue scaffolds obtained by lithography based ceramic manufacture
Knowledge-based tissue scaffolds obtained by lithography based ceramic manufacture

TEAM & CONTACTS

andresAndrés Díaz Lantada, is Associate Professor at the Department of Mechanical Engineering at ETSII-UPM. His research interests are linked to the development of engineering products, mechanical systems and biomedical devices with improved capabilities, thanks to the incorporation of smart materials, special geometries and complex functional structures, mainly attainable by means of additive manufacturing processes. He is currently (since June 2011) Deputy Vice-Dean for Student Affairs and International Relations at the School of Industrial Engineering at the Technical University of Madrid (ETSII-UPM), UPM Contact Researcher at the “European Virtual Institute of Knowledge-Based Multifunctional Materials (KMM-VIN)”, UPM Leader at the “COST Action NewGen: New Generation Biomimetic and Customized Implants for Bone Engineering” and UPM Leader at the “Tomax: Tool-less manufacture of complex geometries” EU-H2020 Factories-of-the-Future Project and at the “UBORA: Euro-African Open Biomedical Engineering e-Platform for innovation through Education” EU-H2020 Infrasupp Project. He has received the “UPM PhD Thesis Extraordinary Award” in 2010, the “UPM Teaching Innovation Award” in 2014, the “UPM Young Researcher Award” in 2014, and the “Medal to Researchers under 40” by the “Spanish Royal Academy of Engineering” in 2015. Since January 2016 he has the honor of being Member of the Editorial Advisory Board of the International Journal of Engineering Education. Since 2015 he takes the lead of the UPM’s Product Development Lab.

Contact: adiaz@etsii.upm.es / Web: www.researchgate.net/profile/Andres_Diaz_Lantada

 

 juanmaJuan Manuel Muñoz Guijosa is Associate Professor in the Department of Mechanical Engineering at  ETSII-UPM. His research activities are linked to several fields of Mechanical Engineering, including vibrations theory, composite materials, microsystem technology and systematic product development. After his award-winning PhD he was visiting researcher at MIT and worked four years for Bosch GmbH linked to the automotive industry. Since his reincorporation to UPM he has been linked to subjects on “Mechanism and Machine Theory”, “Vibrations Theory”, “Engineering Design”, among others, and participated in several research projects. More recently he has been visiting research professor at the Technical University of Tokio (twice, one semester each time) and at Drexel University. He is very active in the field of project-based learning and leads UPM’s “Composites and Nanocomposites Lab”.

 

jose-luisJosé Luis Muñoz Sanz is Associate Professor in the Department of Mechanical Engineering at ETSII-UPM. His research activities are linked to several fields of Mechanical Engineering, including most areas of machine security, machine performance assessment and systematic product development. He incorporates research results to subjects on “Mechanism and Machine Theory”, “Machine Design” and “Machine Security”, and participates in several public- and private-funded research projects, including a European project. He leads the “Mechanisms & Machines Lab” at ETSII – TU Madrid.

 

 

julioJulio Muñoz García is Associate Professor in the Department of Mechanical Engineering at ETSII-UPM. His research activities are linked to mechanical systems, vibration theory, tribological phenomena, biomechanics and biomedical product development. He has been involved in teaching-learning tasks in the fields of Biomechanics and Biomedical Engineering for more than 20 years, being a pioneer in these topics in our University.

 

 

javierJavier Echávarri Otero is Associate Professor in the Department of Mechanical Engineering at ETSII-UPM. His research activities are linked to several fields of Mechanical Engineering, including most areas of tribology and contact phenomena, machine performance assessment and systematic product development. He incorporates research results to subjects on “Machine Design”, “Tribology”, and “Engineering Design”, and participates in several public- and private-funded research projects. He leads a project funded by the Spanish Ministry of Science and Innovation, linked to designing and manufacturing special surfaces for improved tribological performance, and our team’s tribology line.

 

enriqueEnrique Chacón Tanarro is Associate Professor in the Department of Mechanical Engineering at ETSII-UPM. His research activities are linked to several fields of Mechanical Engineering, including most areas of tribology and contact phenomena, machine performance assessment and systematic product development applied to energy engineering. He incorporates research results to subjects on “Machine Design”, “Tribology”, and “Engineering Design”, and participates in several research projects. He has recently been awarded the UPM Extraordinary Prize for his PhD on elasto-hydrodynamic lubrication.

 

pedroPedro Ortego García is Chief Scientific-Technological Laboratory Technician at UPM’s Product Development Lab and has more than twenty years of experience in product and prototype design and manufacture. From prototypes to final products, he masters the use of several design resources, 3D digitalization procedures, additive manufacturing technologies, rapid form copying processes and casting technologies. He supports research, development and innovation tasks in the laboratory in the fields of polymeric, composite, ceramic and metallic materials. He has provided consulting services linked to prototyping activities for academic institutions and enterprises in fields including energy, transport, aerospace and health.

 

 

antonioAntonio Sillero Martínez studied Civil Engineering in Saint Petersburg and joined UPM and the Mechanical Engineering Dept. in the early 80s for supporting the incorporation of ICTs in product design and development. He supports our team with expertise in computer-aided design and engineering and has participated in several public- and private-funded research projects linked to the activities of UPM’s Product Development Lab. He has taken part in CAD-CAE courses for the promotion of employability.

 

 

lealPilar Leal Wiña studied industrial engineering and joined UPM as special lab technician. She carries out research tasks linked to machine security and systematic product development applied to energy engineering, and collaborates in subjects including “Engineering Design” and “Mechanism and Machine Theory”. She has taken part in several public- and private-funded projects, including a European project. She is quality manager in our group.

 

 

Silvia Ortega Pérez is special lab technician in our Machines Engineering Division within the Department of Mechanical Engineering at ETSII-UPM. She supports our team, our teaching-learning experiences and our research lines, especially in connection with the UPM’s Product Development Lab and the UPM’s Mechanisms and Machines Lab, with organizational issues, over-viewing testing campaigns, managing information and helping us to improve our supply chain and our communication with stakeholders.

 Socorro Martín Muela is special lab technician in our Machines Engineering Division within the Department of Mechanical Engineering at ETSII-UPM. She supports our team, our teaching-learning experiences and our research lines, especially in connection with the UPM’s Product Development Lab and the UPM’s Mechanisms and Machines Lab, with organizational issues, over-viewing testing campaigns, managing information and helping us to improve our supply chain and our communication with stakeholders.

 

adrianAdrián de Blas Romero studied industrial engineering and joined us for developing his PhD Thesis linked to advanced additive manufacturing technologies. He has expertise in computer-aided design & engineering and in several additive manufacturing technologies. He has carried out two research stays at the Technical University of Vienna and worked there with the Institute of Materials Science and Technology in additive manufacture applied to non-metallic materials. He is developing his PhD within the “Tomax” EU-H2020 Project, aimed at design optimization and eco-efficient 3D printing processes.

 

guillermoGuillermo Fernández Zapico is researcher with us and has experience in Materials Science and Mechanics of Materials. His Bachelor’s and Master’s theses focused on the mechanical behavior of polymeric-nanocomposites of graphene. Currently he is working on a research project with TALGO (Spanish railway company) developing CFRP and GFRP energy accumulators.

 

 

 

Acknowledgements to our mentors:

 If we have seen further it is by standing on the shoulders of giants

 

pilarPilar Lafont Morgado is Professor Emeritus of Mechanical Engineering. She founded the UPM’s Product Development Lab in 1997 and led it until her retirement in 2015. As researcher she devoted her career to almost all fields of Mechanical Engineering, including: product design and development, development of methodologies for the design of mechanical transmissions, vibrations theory and its implications in machines’ life-cycle, tribology (contact phenomena, lubrication and wear), biomedical applications of Mechanical Engineering principles and related development of medical devices, among others. In all of them she was a pioneer in our country, leading our group towards the foundation of the “UPM’s Research Group in Machines Engineering” and of the “UPM’s Teaching Innovation Group in Machines Engineering”. At the beginning of the 1980s she implemented the first CAD-based project based learning experience in our country, the “EDIMPO Project”, linked to the complete design of a gearbox, which has been continuously improved since then and which is still running. She received the “UPM Teaching Innovation Award” for her innovative teaching-learning experiences.

 

emilioEmilio Bautista Paz is Professor Emeritus of Mechanical Engineering. He began teaching in 1962 as Professor in Mechanical Engineering at the Madrid School of Industrial Engineers, at present, part of UPM. For thirty years, he worked simultaneously at IBM on a part-time basis as Director of Industrial Applications Development. He has been Director of the Madrid School of Industrial Engineers, Director of the Department of Mechanical Engineering, Vice-president of the Senate of Universidad Politécnica de Madrid and Vice-president of the Spanish Tribology Society of the Royal Society of Physics. He was the First President of the Spanish Association of Mechanical Engineering and Vice-president of the Ibero-American Federation of Mechanical Engineering.

In June 2007 he became one of the twelve Honorary Members within IFToMM (the International Federation of Machines and Mechanisms), a honor established to recognize a lifetime of accomplishments in Mechanisms and Machines Science for engineers and scientists with international reputations. In October 2007 he received the Degree of Doctor Honoris Causa from St. Anthony Abbot University of Cusco, Peru, and from Pontifical Catholic University of Peru.

PRESS AND MEDIA

  • On medical applications of 3D printing with cases of study from our lab:

Telemadrid – Zoom: Impresoras 3D, Abril 2014

 

  • On industrial applications of 3D printing with cases of study from our lab:

Telemadrid – Zoom: Impresoras 3D, Marzo 2013

 

  • On the reconstruction of fossils from Atapuerca archaeological site:

Madrid Scientific Films

 

  • On laser stereolithography:

https://www.youtube.com/watch?v=u3H8MhcAqUQ

https://www.youtube.com/watch?v=xlImbD4eLXM

 

 

  • II Feria “El Aprendiz de Ingeniero”, Sept. 2015

Taller Impresion 3DUna demostración sobre las tecnologías de fabricación aditiva industriales y de bajo coste como herramientas fundamentales de apoyo en el proceso de desarrollo de proyectos en múltiples ámbitos de la ingeniería. Es lo que pueden ver los participantes en la actividad titulada “Impresión 3D para productos avanzados”. “Les explicamos cuál es el proceso completo de desarrollo de nuevos productos y como la tecnología 3D ayuda a la ingeniería a verificar esos diseños: ergonomía, estética y todo tipo de funcionalidades”, indica Andrés Díaz Lantada, profesor de la Escuela Técnica Superior de Ingenieros Industriales. Esta tecnología tiene aplicaciones en diferentes campos: desde el sector de la automoción o aeroespacial a la biomedicina o el diseño de juguetes. Pero es “la opción de diseñar geometrías del organismo humano o digitalizar a personas a escala” lo que más llama la atención entre los jóvenes, según explica Díaz Lantada”. (UPM Channel, News).

 

  • “La Uni en la calle”, Mar. 2013

Public talk on: “Prototipos avanzados 3D en el desarrollo de productos”

http://www.escuelaindustrialesupm.com/ingeniero-industrial/monumento-a-la-constitucion-escenario-de-las-aulas-de-etsii/#.V_PCPeWLTIU

DIAGNOCHIP: Design and development of a point-of-care rapid diagnostic system for urinary infections

  • “DIAGNOCHIP: Design and development of a point-of-care rapid diagnostic system for urinary infections”, CORFO, Government of Chile, 2014-2015. Objectives: The DIAGNOCHIP Project aims at the design and development of a point-of-care rapid diagnostic system for urinary infections, which constitutes an urgent need in remote locations without access to state-of-the-art microbiology laboratories and with prevalence of antibiotic resistances. The developed point-of-care lab-on-chip allows for rapid and visual selection of the adequate antibiotics, as the system in fact performs a rapid, cheap and sustainable antibiogram. In collaboration with: Diagnochip SpA, Hospital Universitario La Paz de Madrid, Hospital de la Ribera de Valencia, Hospital Puerta de Hierro de Madrid. diagnochip.cl

diagnochip1

Diagnochip® system and result of the rapid antibiogram.
Diagnochip® system and result of the rapid antibiogram.

i-DENT: New technologies for engineering and manufacturing personalized dental implants and surgical solutions

  • “i-DENT: New technologies for engineering and manufacturing personalized dental implants and surgical solutions”, UPM Call for Collaborative Projects with Latin America, 2014-2015. Objectives: The i-DENT Project is aimed at validating the employment of new CAD-CAE-CAM approaches for the development of personalized solutions in dentistry, including dental implants and splint for guided surgery.
Biomimetic dental implants with porous structure for improved integration.
Biomimetic dental implants with porous structure for improved integration.

KEY PUBLICATIONS

KEY PUBLICATIONS

 

microsystemsHandbook on Microsystems for Enhanced Control of Cell Behavior, Andrés Díaz Lantada, Springer 2016: This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others.

 

 

advancedHandbook on Advanced Design and Manufacturing Technologies for Bio-medical Devices, Andrés Díaz Lantada, Springer 2014: The last decades have seen remarkable advances in computer‐aided design, engineering and manufacturing technologies, multi‐variable simulation tools, medical imaging, biomimetic design, rapid prototyping, micro and nanomanufacturing methods and information management resources, all of which provide new horizons for the Biomedical Engineering fields and the Medical Device Industry. Advanced Design and Manufacturing Technologies for Biomedical Devices covers such topics in depth, with an applied perspective and providing several case studies that help to analyze and understand the key factors of the different stages linked to the development of a novel biomedical device, from the conceptual and design steps, to the prototyping and industrialization phases.

 

 

 

activeHandbook of Active Materials for Medical Devices, Andrés Díaz Lantada, PAN Stanford Publishing – CRC Press 2011: This book focuses on all types of biodevices, mainly implantable or chirurgical, used in the diagnosis or treatment of various pathologies, which benefit from the use of active materials such as sensors or actuators. Such active or “intelligent” materials are capable of responding in a controlled way to various external physical or chemical stimuli by changing some of their properties. These materials can be used to design and develop sensors, actuators, and multifunctional systems with a large number of applications for developing biodevices and medical devices. Current work in this field entails problems related to synthesis, characterization, modelling, simulation, processing, and prototyping technologies, as well as device testing and validation, all of which are treated in depth in this book. The research presented will help future developments in medical devices, based on the additional functionalities that the use of active or “intelligent” materials, both as sensors and as actuators, affords. The results offered in the book will help in the industrial expansion of active materials as part of more complex systems.

Development of a prototype for intra-ocular pressure regulation in glaucoma

  • “Development of a prototype for intra-ocular pressure regulation in glaucoma”, National Programme for the Promotion of Scientific-Technological Development and Innovation, Government of Perú, 2013-2014. Objectives: The Glauco-valve Project aims at the development of a prototype for intra-ocular pressure regulation in glaucoma. The glaucoma valve is designed with the support of FEM simulation resources, based on special texturing procedures and manufactured with the help of additive manufacturing resources. In collaboration with: University of Piura.

glauco1

Rapid prototyped glaucoma valve obtained in medical PDMS
Rapid prototyped glaucoma valve obtained in medical PDMS

FEMAB: Instrumented splint for the diagnosis and management of bruxism

  • “FEMAB: Instrumented splint for the diagnosis and management of bruxism”, Promotion of Tech. Innovation, Ministry of Science and Education. Objectives: The FEMAB project aims at the development of an instrumented splint for the diagnosis and management of bruxism. The system stands out for being developed using polymeric piezoelectric sensors and for the possibility of detecting different types of bruxism and of carrying out quantitative assessments.

femad1

Femab system for the diagnosis of bruxism.
Femab system for the diagnosis of bruxism.

AVAILABLE RESOURCES

AVAILABLE RESOURCES

Regarding materials and equipment, the UPM Product Development Lab counts with several design, prototyping and analysis technologies, including:

  • CAD-CAE-CAM resources for computer aided design, engineering and manufacturing (NX-8.5 Siemens PLM Solutions, Catia, Solid Edge, Matlab, 3-matic by Materialise, among other resources).
  • Additional simulation technologies.
  • Laser stereolithography (3D Systems) for 3D additive manufacture of complex parts.
  • Low-cost laser stereolithography system (Form1+ by Formlabs).
  • Three-dimensional “rep-rap” printer for low-cost production scaffolds and microsystems.
  • “Inkredible” 3D bioprinter and related bioinks for biofabrication purposes.
  • CNC machining for computer aided manufacturing.
  • UV lithography for micromachining of 2D½ geometries.
  • Resources for manufacturing silicone moulds by rapid-form copying.
  • Resources for manufacturing ceramic moulds.
  • Vacuum casting of several biopolymers and alloys in silicone moulds.
  • Microfusion for vacuum casting of metal alloys in ceramic moulds.
  • Composite materials processing technologies.
  • Characterization technologies (mechanical, tribological, thermal).
  • IR-thermography for temperature monitoring in processes and trials.
  • Conventional micro-manufacturing tools (spin-coating, dip-coating, soft/hard-bake, ovens with controllable temperature curves, chemical attack resources optical microscopy…).
  • Several photopolymers (epoxies and acrylics) for additive manufacture and biopolymers (PCL, PVA, PLA, beeswax) for additive manufacture and replication of rapid prototyped “green” parts.
  • PDMS for rapid mold making with replication precision down to 5 microns.
Estereolitografia. SLA 350
Estereolitografia. SLA 350
form1
Form 1+
inkredible
Inkredible