KEY PUBLICATIONS

KEY PUBLICATIONS

 

microsystemsHandbook on Microsystems for Enhanced Control of Cell Behavior, Andrés Díaz Lantada, Springer 2016: This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others.

 

 

advancedHandbook on Advanced Design and Manufacturing Technologies for Bio-medical Devices, Andrés Díaz Lantada, Springer 2014: The last decades have seen remarkable advances in computer‐aided design, engineering and manufacturing technologies, multi‐variable simulation tools, medical imaging, biomimetic design, rapid prototyping, micro and nanomanufacturing methods and information management resources, all of which provide new horizons for the Biomedical Engineering fields and the Medical Device Industry. Advanced Design and Manufacturing Technologies for Biomedical Devices covers such topics in depth, with an applied perspective and providing several case studies that help to analyze and understand the key factors of the different stages linked to the development of a novel biomedical device, from the conceptual and design steps, to the prototyping and industrialization phases.

 

 

 

activeHandbook of Active Materials for Medical Devices, Andrés Díaz Lantada, PAN Stanford Publishing – CRC Press 2011: This book focuses on all types of biodevices, mainly implantable or chirurgical, used in the diagnosis or treatment of various pathologies, which benefit from the use of active materials such as sensors or actuators. Such active or “intelligent” materials are capable of responding in a controlled way to various external physical or chemical stimuli by changing some of their properties. These materials can be used to design and develop sensors, actuators, and multifunctional systems with a large number of applications for developing biodevices and medical devices. Current work in this field entails problems related to synthesis, characterization, modelling, simulation, processing, and prototyping technologies, as well as device testing and validation, all of which are treated in depth in this book. The research presented will help future developments in medical devices, based on the additional functionalities that the use of active or “intelligent” materials, both as sensors and as actuators, affords. The results offered in the book will help in the industrial expansion of active materials as part of more complex systems.

Development of a prototype for intra-ocular pressure regulation in glaucoma

  • “Development of a prototype for intra-ocular pressure regulation in glaucoma”, National Programme for the Promotion of Scientific-Technological Development and Innovation, Government of Perú, 2013-2014. Objectives: The Glauco-valve Project aims at the development of a prototype for intra-ocular pressure regulation in glaucoma. The glaucoma valve is designed with the support of FEM simulation resources, based on special texturing procedures and manufactured with the help of additive manufacturing resources. In collaboration with: University of Piura.

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Rapid prototyped glaucoma valve obtained in medical PDMS
Rapid prototyped glaucoma valve obtained in medical PDMS

FEMAB: Instrumented splint for the diagnosis and management of bruxism

  • “FEMAB: Instrumented splint for the diagnosis and management of bruxism”, Promotion of Tech. Innovation, Ministry of Science and Education. Objectives: The FEMAB project aims at the development of an instrumented splint for the diagnosis and management of bruxism. The system stands out for being developed using polymeric piezoelectric sensors and for the possibility of detecting different types of bruxism and of carrying out quantitative assessments.

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Femab system for the diagnosis of bruxism.
Femab system for the diagnosis of bruxism.

AVAILABLE RESOURCES

AVAILABLE RESOURCES

Regarding materials and equipment, the UPM Product Development Lab counts with several design, prototyping and analysis technologies, including:

  • CAD-CAE-CAM resources for computer aided design, engineering and manufacturing (NX-8.5 Siemens PLM Solutions, Catia, Solid Edge, Matlab, 3-matic by Materialise, among other resources).
  • Additional simulation technologies.
  • Laser stereolithography (3D Systems) for 3D additive manufacture of complex parts.
  • Low-cost laser stereolithography system (Form1+ by Formlabs).
  • Three-dimensional “rep-rap” printer for low-cost production scaffolds and microsystems.
  • “Inkredible” 3D bioprinter and related bioinks for biofabrication purposes.
  • CNC machining for computer aided manufacturing.
  • UV lithography for micromachining of 2D½ geometries.
  • Resources for manufacturing silicone moulds by rapid-form copying.
  • Resources for manufacturing ceramic moulds.
  • Vacuum casting of several biopolymers and alloys in silicone moulds.
  • Microfusion for vacuum casting of metal alloys in ceramic moulds.
  • Composite materials processing technologies.
  • Characterization technologies (mechanical, tribological, thermal).
  • IR-thermography for temperature monitoring in processes and trials.
  • Conventional micro-manufacturing tools (spin-coating, dip-coating, soft/hard-bake, ovens with controllable temperature curves, chemical attack resources optical microscopy…).
  • Several photopolymers (epoxies and acrylics) for additive manufacture and biopolymers (PCL, PVA, PLA, beeswax) for additive manufacture and replication of rapid prototyped “green” parts.
  • PDMS for rapid mold making with replication precision down to 5 microns.
Estereolitografia. SLA 350
Estereolitografia. SLA 350
form1
Form 1+
inkredible
Inkredible

Teaching Innovation

“CDIO” IN MECHANICAL AND BIOMEDICAL ENGINEERING

According to our experience, the graduates and post-graduates from multidisciplinary engineering programmes, including Industrial and Mechanical Engineering, can play varied and very relevant roles in several industries (including transport, energy, health and aerospace) and in extremely complex product development projects. We carry out teaching-learning experiences in several subjects and UPM programmes linked to Industrial, Mechanical and Biomedical Engineering, including: “Engineering Design” and “Bioengineering Design” in the Master’s Degree in Industrial Engineering, “Bioengineering” in the Master’s Degree in Mechanical Engineering, “Machine Design” in the Bachelor’s Degree in Industrial Technologies and “Development of Medical Devices” in the Bachelor’s Degree in Biomedical Engineering. We incorporate research results into the different subjects and try to promote project-based learning following the CDIO (conceive-design-implement-operate) approach, enabling students to live through the complete development process of novel innovative engineering systems and products.

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Example of students’ developments linked to machines: Gear pump and “gerotor” gearbox.
Example of students’ developments linked to machines: Gear pump and “gerotor” gearbox.

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Example of students’ developments linked to a sternum-rib and shoulder prostheses.
Example of students’ developments linked to a sternum-rib and shoulder prostheses.

 

Additional information:

  • Díaz Lantada, A.; Ros Felip, A.; Jiménez Fernández, J.; Muñoz García, J.; Claramunt Alonso, R.; Carpio Huertas, J..- “CDIO experiences in Biomedical Engineering: Preparing Spanish students for the future of medicine and medical device technology”. 12th International CDIO Conference, Turku, Finland, June, 2016.
  • Muñoz-Guijosa, J.M.; Díaz Lantada, A.; Chacón Tanarro, E.;, Echávarri Otero, J.; Muñoz Sanz, J.L.; Muñoz García, J..- “Engineering Design course transformation: From a conceive – design towards a complete CDIO approach”. 12th International CDIO Conference, Turku, Finland, June, 2016.
  • Díaz Lantada, A.; Ros Felip, A.; Jiménez Fernández, J.; Muñoz García, J.; Claramunt Alonso, R.; Carpio Huertas, J..- “Integrating Biomedical Engineering Design into Engineering curricula: Benefits and challenges of the CDIO approach”. 11th International CDIO Conference, Cheng-Du, China, 2015.
  • http://www.cdio.org/node/6192

 

Promotion of Science, Technology & Society approaches

Science and Technology are part of every branch of modern life and fundamental for the future and sustainability of Society. At the same time, only in intimate contact with the needs and problems of people can we drive the scientific-technological advances towards the adequate directions, aimed at building a more harmonic global civilization with healthier societies. In consequence, as part of our research, we focus on the application of our experience and resources to objects connected with our every-day life, focusing on the needs of people and trying to attract talent for building together the future of Science, Technology and Society, which is linked to the promotion of scientific-technological vocations. Among the more relevant aspects, in which we focus, it is important to cite:

  • Attendance to and organization of events for promoting scientific-technological vocations.
  • Scientific divulgation videos, reports and events on product design.
  • Scientific divulgation videos, reports and events on additive manufacturing.
  • Models for technical presentations and benchmarking purposes.
  • Models for exhibitions, fairs and contests, including architectural models.
  • Models for toy makers and prototypes of parts and molds for the toy industry.
  • Models for the jewelry and fashion industries, which benefit from 3D printing.
  • Reconstructions, reproductions and master models of artistic objects and sculptures.
  • Teaching-learning activities linked to product design (see Section on Teaching Innovation).
Examples of students’ design within the “Toy Design Experience” in the “Design and Manufacturing with Polymers” course (Master’s Degree in Industrial Engineering, UPM).
Examples of students’ design within the “Toy Design Experience” in the “Design and Manufacturing with Polymers” course (Master’s Degree in Industrial Engineering, UPM).

Surface design and functionalization of materials and products

Material (and device) surface topography has a direct influence on several relevant properties, linked to its final performance, such as friction coefficient, wear resistance, self-cleaning ability, biocompatibility, optical response and properties, touch perception, overall aesthetic aspect and even flavor. Therefore it also plays a determinant role in material selection in engineering design, especially in the field of micro- and nano-system development, in which the effects of topography on the incorporation of advanced properties are even more remarkable. The possibility of manufacturing textured materials and devices, with surface properties controlled from the design stage, instead of being the result of machining processes or chemical attacks, is a key factor for the incorporation of advanced functionalities to a wide set of micro and nanosystems. In our lab, high-precision additive manufacturing technologies based on photo-polymerization, together with the use of fractal and math-based models linked to computer-aided design tools, allow us to precisely define and control of final surface properties. In this fascinating field of research and development, we usually dedicate our efforts to the following topics:

  • Design of bioinspired surfaces based on math-based approaches.
  • Control of surface topography and micro-texture from the design stage.
  • Design and development of hydrophobic / hydrophilic patterns for enhanced tribology.
  • Incorporation of desired surface properties to final applications.
  • Improved ergonomics, aesthetics, optical properties and contact phenomena.
Examples of bioinspired surface designs and probes with design-controlled surface features.
Examples of bioinspired surface designs and probes with design-controlled surface features.

Knowledge-based design of complex geometries for improved functionality

viii) Knowledge-based design of complex geometries for improved functionality

Additive manufacturing technologies, by working on a layer-by-layer approach, enable solid free-form manufacture and the production of materials, devices and products with complex geometries impossible to obtain otherwise. Geometrical complexity can be used to integrate several functions in a single part, to optimize the number of components of engineering systems and to reduce the manufacturing steps involved in mass-production. Such geometrical complexity is also interesting for the promotion of biomimetic designs, for improving ergonomics and for enhancing mechanical, dynamical, thermal and fluidic functionalities following bioinspired design strategies and other theories for the generation of innovative and efficient designs, such as the constructal law. At the same time, geometrical complexity is inherent to topological optimization and to other optimization procedures aimed at minimizing material consumption and maximizing certain functionalities per mass unit. As regards the design and tool-less manufacture of complex geometries, we are actively working in research and development lines including:

  • Design of bioinspired support structures for eco-efficient additive manufacture.
  • Design and application of lattice and porous structures for developing metamaterials
  • Design and application of complex geometries for special properties (i.e. auxetics).
  • Design and application of lattice and porous geometries for efficient product development.
  • Design and application of complex geometries for efficient product development.
  • Topological optimization procedures towards improved resistance vs. weight.
  • Topological optimization procedures towards improved mass distributions.
Examples of complex geometries attainable by means of additive manufacturing technologies.
Examples of complex geometries attainable by means of additive manufacturing technologies.

THE PRODUCT DEVELOPMENT LAB

upmindustrialesTHE PRODUCT DEVELOPMENT LAB

Two decades designing prototypes and products for the future
Mechanical Engineering Department, ETSI Industriales,
Universidad Politécnica de Madrid (UPM)

ABOUT US
The Product Development Lab was founded at Universidad Politécnica de Madrid in 1997 by Chair Prof. Pilar Lafont as the first digital design and manufacturing “fab-lab” in our university and the first one to count with a high-performance industrial additive manufacturing laser stereolithography system in Spain. Since then, a group of passionate researchers and teachers from the Mechanical Engineering Department at the ETSI Industriales of the Universidad Politécnica de Madrid (Industriales UPM) work together for reshaping product development and for setting the foundations towards the future of Engineering and Product Design.

Consequently, the UPM’s Product Development Lab is pioneer in our country in the fields of computer-aided design, engineering and manufacturing, as well as in the use of rapid prototyping and additive manufacturing technologies (commonly referred to as 3D printing technologies) for the development of prototypes and final products with complex geometries, high level of detail and using polymeric, ceramic, metallic and composite materials.

We aim:

“To promote the development of innovative products in all kinds of industries by the systematic application of advanced design, engineering and manufacturing technologies and by taking advantage of the use of modern materials”.

“To help enterprises, technological centers and researchers to improve their products by including special functionalities and by design optimization strategies”.

We seek to jointly employ systematic product development methodologies, advanced design and manufacturing technologies and innovative testing procedures for the straight-forward development of advanced products within several industries, including health, energy, transport and space, among others, for the benefit of Society.

In addition, we expect to prepare our students for the future of Engineering, which will for sure benefit from the progressive incorporation of Mechanical Engineering principles to the aforementioned systematic methodologies and from the combined use of multi-disciplinary design/modelling tools and additive manufacturing technologies, towards advanced engineering systems with enhanced performance. Innovative project-based learning methodologies, based on the CDIO (“conceive-design-implement-operate”) approach, are fundamental for the desired shift and allow us to incorporate research results into daily lessons.

Main lines of research, innovation and translation for the Product Development Lab at UPM initiative include:

We collaborate with technological and academic institutions worldwide, as well as with enterprises and foundations devoted to product development in all Engineering areas. We are also promoting collaborative open source co-design strategies for the development of new solutions to face the current and future global challenges.

If you are also passionate about building the future of Engineering and Product Design, please contact and join us.

Contact:
Andrés Díaz Lantada, Associate Professor, Lab’s leader, adiaz@etsii.upm.es

Address:
Laboratorio de Desarrollo de Productos
ETSI Industriales, Universidad Politécnica de Madrid
c/ José Gutiérrez Abascal 2, 28006 Madrid, Spain

 

madrid

Red de Laboratorios e Infraestructuras de la Comunidad de Madrid (REDLAB)
172 – Laboratorio de Desarrollo de Productos    

 

Publicada en LDP

Knowledge-based design of multifunctional / advanced materials

Numerous active, multipurpose or “smart” materials have appeared in recent decades, all capable of responding in a controllable way to different external physical and chemical stimuli by changing some of their properties. These materials can be used to design sensors, actuators and multipurpose systems. In addition, special “metamaterials” are designed to obtain desired properties by means of adequately defining and controlling their microstructure. All these materials can be considered “knowledge-based”(for the special design requirements involved in their selection and application) and “multifunctional” (for their unique properties connecting different domains of Physics and Chemistry) materials. Since 2012 we actively collaborate with the “European Virtual Institute on Knowledge-Based Multifunctional Materials” (KMM-VIN) (http://kmmvin.eu), especially in tasks linked to materials modelling and to biomedical applications of innovative biomaterials, having hosted its 5th Industrial Workshop on “Multi-scale and multi-physics materials modelling for advanced industries”.
http://kmmvin.eu/system/files/u279/kboch/Uloaded/KMM-VIN_Workshop_Madrid_2016_Booklet.pdf

Among the activities we perform linked to knowledge-based multifunctional & advanced materials, mainly focused to smart materials and mechanical metamaterials, we highlight:
– Knowledge-based design of smart materials & metamaterials.
– Characterization, modelling and simulation of smart materials & metamaterials.
– Industrial applications of smart materials & metamaterials.
– Manufacture of smart materials & metamaterials and of applications based on them.

Examples of smart materials and metamaterials: Design, models, prototypes, applications. SEM images of prototypes obtained in collaboration with KNMF-KIT.
Examples of smart materials and metamaterials: Design, models, prototypes, applications.
SEM images of prototypes obtained in collaboration with KNMF-KIT.